Dr. Udo Doebbeling : Publications

Dr. Udo Döbbeling
University Hospital Zürich
Dept. of Dermatology

List of Publications

Journal Articles

Döbbeling, U., Ross, K., Klein-Hitpass, L., Morley, C., Wagner, U. and Ryffel, G.U. (1988).
A cell-specific activator in the Xenopus A2 vitellogenin gene: promoter elements functioning with rat liver extracts. EMBO J. 7, 2495-2501.

Schorpp, M., Döbbeling, U., Wagner, U. and Ryffel, G.U. (1988).
5' -flanking and 5' -proximal exon regions of the two Xenopus albumin genes. Deletion analysis of constitutive promoter function. J. Mol. Biol. 199, 83-93.

Wieland, S., Döbbeling, U. ,and Rusconi, S. (1991).
Interference and synergism of glucocorticoid receptor and octamer factors. EMBO J. 10, 2513-2521.

Zandi, E., Galli, I., Döbbeling, U. and Rusconi, S. (1993).
Zinc finger mutations that alter domain interactions in the glucocorticoid receptor.
J. Mol. Biol. 230, 124-136.

Döbbeling, U., and Berchtold, M.W. (1996).
Down regulation of the protein kinase A pathway by activators of protein kinase C and intracellular calcium in fibroblast cells.
FEBS LETTERS 391, 131-133.

Döbbeling, U., Hobi, R., Berchtold, M.W., and Kuenzle, C.C. (1996).
Intracellular signalling pathways converge on RAG gene expression to regulate V(D)J recombination.
J. Mol. Biol. 261, 309-314.

Döbbeling, U. (1996).
The transcription factor Oct2A enhances V(D)J recombination in fibroblasts.
Scand. J. Immunol. 44, 323-329.

Döbbeling, U. (1996).
The effect of transfected mutant and wild type RAG genes in different cell types.
Immunol. Invest. 25, 469-479.

Döbbeling, U. (1996)
The influence of IL-7 on V(D)J recombination.
Immunology 89, 569-572.

Scheier, B., Foletti, A., Stark, G., Aoyama, A., Döbbeling, U., Rusconi, S., and Klemenz, R. (1996).
Glucocorticoids regulate the expression of the stress protein alpha B-crystallin.
Mol. Cell. Endocrinol. 123, 187-198.

Döbbeling, U., Böni, R., Häffner, A., Dummer, R., and Burg, G. (1997)
Method for simultaneous RNA and DNA isolation from biopsy material, culture cells, plants and bacteria.
BioTechniques 22, 88-90.

Döbbeling, U. (1997).
The effects of cyclosporin A on V(D)J recombination activity.
Scand. J. Immunol. 45, 494-498.

Hassam, S.H., Meyer, J.C., Dummer, R., Muletta, S., Döbbeling, U., Dommann, S.N.W., and Burg, G.(1997).
A realistic approach to the sensitivity of PCR-DGGE and its application as a sensitive tool for the detection of clonality in cutaneous T-cell proliferations.
Experimental Dermatology 6, 122-127.

Döbbeling, U., Dummer, R., Hess Schmid, M., and Burg, G. (1997).
Lack of expression of the recombination activating genes RAG-1 and RAG-2 in cutaneous T cell lymphoma (CTCL): Pathogenetic implications.
Clinical and Experimental Dermatology 22, 230-233.

Döbbeling, U., Dummer, R., Laine, E., Potoczna, N., Qin, J-Z., and Burg, G. (1998).
IL-15 is an autocrine/paracrine viability factor for cutaneous T cell lymphoma cells.
Blood 92, 252-258.

Qin, J.Z., Dummer, R., Burg, G., and Döbbeling, U. (1999).
Constitutive and IL-7/Il-15 stimulated DNA-binding of Myc, Jun, and novel Myc-like proteins in cutaneous T cell Lymphoma cells.
Blood, 93, 260-267.

Laetsch, B., Häffner, A.C., Döbbeling, U., Seifert, B., Ludwig, E., Burg, G., and Dummer, R. (2000).
CD4+/CD7-T-cell frequency and PCR-based clonality assay correlate with stage in CTCL. J. Invest. Derm., 114, 107-111.

Dummer, R., Döbbeling, U. , Geertsen, R., Willers, J., Burg, G., and Pavlovic, J. (2001).
Interferon resistance of cutaneous T-cell lymphoma-derived clonal T-helper 2 cells allows selective viral replication. Blood, 97, 523-527.

Qin, J-Z., Kamarashev, J., Zhang, C-L, Dummer, R., Burg, G., and Döbbeling, U. (2001).
Constitutive and IL-7 and IL-15 stimulated DNA-binding of STAT and novel factors in cutaneous T cell lymphoma (CTCL) cells.
J. Invest. Derm., 117, 583-589.

Qin, J-Z., Zhang, C-L., Kamarashev, J., Dummer, R., Burg, G., and Döbbeling, U. (2001).
IL-7 and IL-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T cell lymphoma (CTCL) cells.
Blood, 98, 2778-2783.

Zhang, C., Kamarashev, J., Qin, J-Z., Burg, G., Dummer, R., and Döbbeling, U. (2003)
Expression of Apoptosis Regulators in Cutaneous T Cell Lymphoma (CTCL) Cells.
J. Pathol., 200, 249-254.

Roberts, A.A., Amano, M., Felten, C., Galvan, M., Sulu, G., Pinter-Brown , L., Döbbeling, U., Burg, G., Said , J., Baum, LG. (2003) Galectin-1-Mediated Apoptosis in Mycosis Fungoides: The Roles of CD7 and Cell Surface Glycosylation.
Mod. Pathol. 16, 543-51.

Review Articles and Comments

Dummer, R., Davis-Daneshfar, A., Döhring, C., Döbbeling, U., and Burg, G. (1995).
Strategien zur Gentherapie des Melanoms (strategies for gene therapy in melanoma).
Hautarzt 46, 305-308.

Burg, G., Dummer, R., Nestle, F.O., Döbbeling, U., and Häffner, A. (1996).
Cutaneous lymphomas comprise a spectrum of nosologically different entities including mycosis fungoides and small plaque parapsoriasis.
Arch. Dermatol. 132, 567-571.

Burg,G., Kempf, W., Häffner, A.C., Nestle, F.O., Hess Schmid, M., Döbbeling, U., Müller, B., and Dummer, R. (1997). Cutaneous Lymphomas. Curr. Probl. Dermatol. 9, 139-204.

Kempf, W., Dummer, R., Müller, B., Döbbeling, U., Häffner, A., Nestle, F.O., and Burg, G. (1998).
Cutaneous lymphoproliferative infiltrates - entities, concepts, and a new clinically oriented approach beyond the classifications. Kor. J. Invest. Derm. 5, 103-120.

Döbbeling, U. (1999).
The regulation of rag gene expression and V(D)J recombination by different signalling pathways. Recent Res. Devel. Immunology 1, 375-397.

Dummer, R., Willers, J., Kamarashev, J., Urosevic, M., Döbbeling, U., and Burg, G. (2000).
Pathogenesis of cutaneous lymphomas. Seminars in Cutaneous Medicine and Surgery, 19, 78-86.

Dummer, R., Willers, J., Döbbeling, U., and Burg, G. (2001).
Aktuelle Aspekte zur Pathogenese von Sézary Syndrom und mycosis fungoides (New aspects of the pathogenesis of Sézary syndrom anf Mycosis fungoides). Hautarzt, 52, 189-192.

Döbbeling, U. (2002).
Why human T-cell lymphotropic virus-1 Tax is not the cause of cutaneous
T-cell lymphoma. Blood, 99, 3488-3489.

Burg, G., Kempf, W., Haeffner, A., Döbbeling, U., Nestle, F.O., Boni, R., Kadin, M., and Dummer, R. (2002)
From inflammation to neoplasia: new concepts in the pathogenesis of cutaneous lymphomas. Recent Results Cancer Res. 160, 271-80.

Dummer, R., Urosevic, M., Döbbeling, U., and Burg, G.
Immunobiology of cutaneous T-cell lymphomas (2003). Haematologica, 88 (suppl.5), 25-29.

Book Articles

Ryffel, G.U., Klein-Hitpass, L., Drüge, P., Döbbeling, U., Heitlinger, E., and Cato, A.C.B. (1988)
The estrogen-responsive DNA element: structure and interaction with the estrogen receptor. Steroid hormone action pp. 219-225, Alan Liss Inc.

Dummer, R., Dommann, S.N.W., Hassam, S.H., Böni, R., Döbbeling, U., Nestle, F.O., and Burg, G. (1994).
Diagnostics and pathogenesis of cutaneous lymphoma, Yearbook of Dermatology pp 151-164, eds. Macher, E., Kolde, G., and Bröcker, E.B., Biermann Verlag GmbH. ISBN 3-924469-95-4.

Burg, G., Dummer, R., Domman, S., Böni, R., Döbbeling, U. and Nestle, F. (1995).
Malignant Lymphoma of the skin in : Morbus Hodgkin and Non-Hodgkin-Lymphoma pp 127-150, Editors: Diehl, V., Schlag, R., and Thiel, E., Karger Verlag Basel.

Dummer, R., Böni, R., Döbbeling, U., Nestle, F., and Burg, G. (1996).
Melanoma therapy- immunological evaluation after excision). In : Surgical and conservative dermatooncology in the inter-disciplinary area; progress in surgical and oncological dermatology, R. Dummer, R. Panizzon, G. Burg (Eds.), Blackwell Berlin volume 11, 189-193.

Meyer, J.C., Hassam, S., Dummer, R., Muletta, S., Döbbeling, U., Dommann, S.N.W., and Burg, G. (1996).
Proof of clonality in cutaneous T cell lymphoma: comparison of PCR-DGGE of the T cell receptor gamma gene to Southern blot analysis (SBA) of the T cell receptor beta gene. In: Surgical and conservative dermatooncology in the interdisciplinary area; progress in surgical and oncological dermatology, R. Dummer, R. Panizzon, G. Burg (Eds.), Blackwell Berlin volume 11, 208-211.

Dummer, R., Döbbeling, U., Geertsen, R., Willers, J., and Burg, G. (1999).
Pathogenese kutaner T-Zell-Lymphome (Pathogenesis of cutaneous T cell lymphoma). In: Dermatologie an der Schwelle zum neuen Jahrtausend, pp 455-456, A. Plettenberg, W.N. Meigel, , I. Moll (Eds.), Springer Verlag.

Döbbeling, U. (1999).
Simultaneous RNA and DNA extraction from biopsy material, culture cells, plants, and bacteria, in "The Nucleic Acids Protocols Handbook", pp 53-56. Editor: Ralph Rapley.
Humana Press Totowa N.Y.

Published poster abstracts

In total 40 published poster abstracts. 15 of them were published in the Journal of Investigative Dermatology, 9 in Experientia, 6 in the Archives of Dermatological Research, 2 in Zentralblatt Haut, and the Annals of Oncology, 1 each in The Journal of Cancer Research and Clinical Oncology, Allergologie, European Journal of Cell Biology, Aktuelle Dermatologie, and Dermatologica Helvetica.
Some of them were given as oral presentations (see below).

Oral presentations

The following three abstracts were given by me as oral presentations:

Qin, J.-Z., Nestle, F.O., Häffner, A., Dummer, R., Burg, G., and Döbbeling, U. (1997). Cutaneous T cell lymphoma cells contain constitutive NFkB-DNA complexes.
J. Invest. Dermatol. 108, 575.
27th Annual Meeting of the Society of Investigative Dermatology in Washington D.C.

Qin, J.-Z., Dummer, R., Burg, G., and Döbbeling, U. (1997).
Subunit composition of Jun and Myc DNA-binding complexes in CTCL cells.
J. Invst. Derm. 109, 488.
ESDR Symposium Cutaneous Malignant Lymphomas, Berlin.

Döbbeling, U., Kamarashev, J., Dummer, R., and Burg, G. (2003). Expression und Phosphorylierung von Src-Tyrosin-Kinasen in kutanen T-Zell-Lymphomen (CTCL). Aktuelle Dermatologie 29, 379.

Further oral presentations were given at the annual meetings of the Swiss Sociey of Oncology (SGO/SSO) in Bern (1994, 1995, 1996) and Lausanne (1997) and meetings of the European Organization for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Project Group in Barcelone (1994, Munich (1996), Essen (2000) and the 5th Asian Dermatological congress in Beijing (1998).

Master- and Doctoral Theses

Döbbeling, U. (1984).
Cloning of MMTV-related genes by recombinant vectors. Master thesis (Diplomarbeit), University of Karlsruhe.

Döbbeling, U. (1988).
Regulatory elements of the albumin and vitellogenin genes of the clawed frog Xenopus laevis: Identification of a cell-specific activator in the vitellogenin A2 gene. Ph. D. thesis, University of Karlsruhe.